Regenerative medicine is a cellular-level therapy that aims to improve the function of damaged or diseased tissue or organs by introducing cells to replace damaged cells. Today, regenerative medicine is being used to treat medical conditions across a range of medical specialties, including orthopedics, rheumatology, cardiology, neurology, and immunology.
How Stem Cells Work
When an area of the body is injured or not functioning properly, distress signals are sent through the bloodstream. These signals serve to recruit mesenchymal stem cells to the affected area.
Once in the affected area, stem cells dock on other cells and begin to produce signalling proteins that work to regulate inflammation, aid in angiogenesis, and promote tissue repair.
Stem cells then mature to carry out the functions of the cells that are needed. In this way, they compensate for the cells that are damaged, nonfunctional, or lacking to improve organ function, and consequently improve disease symptoms.
What Makes Mesenchymal Stem Cells (MSCs) Different?
Mesenchymal Stem Cells (MSCs) have a special ability to move to specific tissues, going where the body needs them most. This means that stem cells can be injected into the bloodstream to then move on their own to the affected area.
In the case of tissue damage, MSCs have the ability to release growth factors and specialize into a number of tissue cell types that allow for the tissue to be regenerated.
When foreign cells are introduced in the body, the concern is that they will often generate an immune response. Because MSCs express very few antigens on their surfaces that can generate an immune response (like MHCI or MHCII), they do not elicit a reaction from the patient’s immune system T-cells, making them safe to use.
REDUCTION OF INFLAMMATION
MSCs reduce the signal cells that promote inflammation (like TNF-alpha and TNF-gamma). While this is another function that helps them to avoid the immune response, it is also essential to stem cells’ utility in chronic and autoimmune diseases characterized by inflammation.
Who Is It For?
Treatments are designed to work for both athletes recovering from injuries and those who experience chronic pain. Amnion-derived fluid has potential clinical benefits in a variety of applications and has been used to treat injuries such as:
- Plantar Fasciitis
- Ruptured Achilies Tendon
- Osteo-Chrondral Defects
- Labral Tears Shoulder/Hip
- Flexor Tendon Repair
- Hip Abductor/Adductor Tears
- Knee Injections
- MCL/LCL Tears
- Rotator Cuff Lesions
- Epicondylitis (Tennis Elbow)
- Hamstring Strains/Tears
- Chronic Non-Healing Wounds
- Ankle Sprain