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Pain Management With Peptide Therapy

WHAT IS TB 500

TB-500 is a synthetic peptide of the naturally occuring healing protein present in about all human and mammalian cells known as Thymosin Beta 4 (TB4). TB 500 is thought to have beneficial effects on wound healing, injury recovery, flexibility, and inflammation. Research indicated the effects of TB 500 are on blood cell and blood vessel development, cellular differentiation, and cell migration. The healing capability is due in large from the peptide’s regulation of actin, a cell building protein essential to healing and wound repair.

TB 500 is produced in the thymus gland and is found in high concentrations in wound fluids. Research demonstrates it has wound healing properties in addition to healing and repair of skin, cornea, and heart.

TB-500 is a naturally occurring peptide also found in high concentrations in blood platelets. TB-500 peptides for research are not growth factors; rather major actin regulating protein peptides. TB 500 plays an important role in protection, regeneration and remodeling of injured and/or damaged tissues. The gene that codes for Thymosin Beta-4 was noted in a study to be one of the first to be stimulated after an incident of injury.

Present in almost all human and animal cells, Thymosin Beta 4 is naturally occurring wound healing peptide. TB 500 , a synthetically made version of TB4 that facilitates comparable healing and recovery by helping building new blood vessels, muscle tissue fibers, blood cells, and facilitating cell migration. For a stressed and injured person, TB 500 can offer an extremely desirable wound healing effects.

HOW DOES TB 500 WORK

TB 500 aids in recovery by increasing actin. By up-regulating this cellular protein, TB 500 is able to boost actin’s positive effects. Actin helps to promote cell migration and proliferation. As a result, new blood vessels form and inflammation can be regulated so that healing and recovery are optimized. In addition, TB 500 can travel a long distance in the body because of its unique molecular structure. Therefore systemic effects occur to help both local and distant sites of injury including reduced inflammation and optimizing flexibility. A noted benefit vs side effect is the regrowing and darkening of hair.

WHAT ARE THE BENEFITS OF TB 500

 

  • Enhanced Recovery
  • Reduced Inflammation
  • Improved Flexibility
  • Aid Recovery of Slow Healing Injuries such as those to connective tissue, i.e. tendons and ligaments
  • Boost Muscle injuries recovery
  • Promote healing of skin injuries

 

WHAT IS THE DOSE OF TB-500

TB500 comes as a lyophilized (freeze dried)powder that needs to be reconstituted with bacteriostatic sodium chloride 0.9%.

Doses can range from 5 mg to 20 mg per week by SQ or IM injections divided into 2-3 injections per week. It is then lowered after the first 1-2 weeks to a maintenance dose approximately 1/2 of the original weekly dose and administered once a week thereafter.

WHAT ARE THE SIDE EFFECTS OF TB 500

There are many positive effects associated with Tb500 use, including enhanced recovery, reduced inflammation, and improved flexibility. The peptide works very effectively to aid recovery of slow healing injuries such as those to connective tissue, i.e. tendons and ligaments. Muscle injuries and injuries to skin are greatly helped as well. From reports from users and researchers around the globe, TB 500 seems to cause very few, if any, serious negative side effects.

Most peptides generally can produce a lightheadedness or nauseous feeling upon injection. Also, flu-like symptoms are prevalent among many other peptides as well. However, the incidence of these negative side effects occurring with TB500 administration is reported to be very low, if at all. TB 500 appears to be a very well tolerated peptide among users.

**This item is only available with a medical consultation. During your consultation with the medical provider, you will discuss a plan that best suits your goals. This product is not FDA approved and therefore outside of clinical use, but substantial information is available on its role in clinical observational trials**

HEALING, FLEXIBILITY, INJURY PROTECTION

WHAT IS BPC 157

Body Protection Compound 157, is a fragment of a protein found in gastric juice. Its tissue-regenerative ability isn’t limited to our stomachs, however. In fact, BPC-157 has been found to promote increased healing and repair in nearly every kind of tissue in which it has been studied.

BPC-157 is a synthetic version of a compound found naturally in the stomach that is thought to be a healing protein. Some studies have shown accelerated healing in animals and shorter recovery time. Other studies have noted potential benefit for improving mobility, strength, and flexibility in joints and connective tissue.

BPC-157 is may have benefit for brain function as well as accelerated wound recovery. Some claim it to have powerful healing effects on tendon, ligament, and joint tissue but more studies need to be completed. Animals studies have shown a protective effect on the musculoskeletal tissue, joints, and neurological tissue of performance.

SERMORELIN (GRF 1-29)

Sermorelin stimulates growth hormone production and results in increased muscle mass, lowers body fat, improves recovery, enhances sleep, improves flexibility and joint health, and optimizes overall health and wellness.

WHAT IS SERMORELIN

Sermorelin is a synthetically made version of growth hormone releasing hormone (GHRH). GHRH is normally made in the body is responsible for stimulating natural growth hormone production. I is typically categorized as a growth hormone secretagogue, a compound which stimulates increased secretion of growth hormone from the pituitary gland.

Sermorelin, like the body’s natural GHRH, works primarily by binding to the GHRH receptor in the anterior part of the pituitary gland. There, it stimulates additional release of GH, which in turn increases the production of endogenous IGF-1. IGF-1 is the active hormone that causes all the positive outcomes. Sermorelin acts in an identical manner to GHRH thus causing release of GH. One of the benefits of using Sermorelin vs IGF-1 is it works by a negative feedback system, so when too much is noted to be in the body, it prevents unhealthy levels of GH. It also mirrors the natural fluctuations of GH concentrations in the body which causes less side effects.

In addition, its natural action mechanism allows for the preservation of the hypothalamic-pituitary-somatotropic axis and prevents the shutdown of hormone production that typically accompanies direct replacement with hGH. Finally, Sermorelin has also been shown to improve sleep quality, enhancing the duration of restorative slow wave sleep and amplifying sleep-related secretion of growth hormone while reducing production of cortisol.

BENEFITS

  • naturally improves growth hormone production
  • increased muscle
  • increased lean body mass
  • decreased body fat
  • enhanced recovery from injuries and training sessions
  • better sleep; deeper, more restful sleep
  • improved flexibility and joint health
  • enhanced overall health and wellness
  • increased levels of GH stimulate greater production of Insulin-like Growth Factor 1 (IGF-1) in the body, further driving improvements in lean body composition with accelerated growth of muscle tissue and reduced body fat

Lower than optimal levels of growth hormone in the body can significantly affect an individual’s athletic performance, functional capacity, and overall quality of life. Growth hormone is a crucial component in numerous physiological processes: increased strength, energy, flexibility, vitality, and overall well-being. Suboptimal levels of growth hormone levels is often associated with loss of muscle mass and strength, weaker bones, reduced exercise capacity, increased body fat, decreased stamina, poor recovery, and unrestorative sleep.

Difference between Sermorelin and Modified GRF 1-29

Sermorelin is often confused with Modified GRF 1-29. They are both similar but these two peptides do have an important difference. These two peptides have a molecular structure comprised of 29 amino acids and possess comparable mechanisms of action (mimicking GHRH to stimulate endogenous GH production). On the other hand, Modified GRF 1-29 has been altered with changes to four specific amino acids in its chemical structure. These changes are intended to increase the peptide’s stability during storage, transportation, and administration while enhancing its affinity for the GHRH receptor.

Combinations of Peptides

Many peptides work well alone, but when they are combined with another peptide they are considered to have a synergistic effect, meaning the effects of both peptides are henced but combining them then using them alone. To enhanced GH production, peptides such as GHRP-2, GHRP-6, or Ipamorelin in combination with Sermorelin can result in a powerful synergistic effect. These peptides’ complementary mechanisms of action can stimulate even greater secretion of GH, resulting in augmented IGF-1 production, improved muscle tissue growth and repair, accelerated wound healing and recovery, enhanced fat metabolism (fat loss), and more powerful anti-aging effects.

SIDE EFFECTS

Side effects of Sermorelin are generally mild and may include:

  • flushing
  • dizziness
  • headache
  • mild pain if any at injection site immediately after administration
  • sleepiness (hence being given at night)
  • interaction with glucocorticoid (steroids)

In most cases, any side effects tend to lessen with continued use.

DOSAGE

Sermorelin dosages commonly range from 200mcg (0.2mg) to 1000mcg (1mg)  given 1 to 3 times daily. The peptide is commonly administered once daily before bed or split into 2 – 3 smaller doses spread throughout the day.

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